Missy Elliott

The music icon took an extended, high-profile break from the entertainment industry following a severe diagnosis of Graves' disease, an autoimmune condition that aggressively impacts the thyroid.

A primary side effect for the rapper was thyroid eye disease, which causes acute physical discomfort, swelling, and severe vision issues. Reassuring fans during her triumphant comeback, the Get Ur Freak On artist stated: "I'm feeling so much better now... outside of that, I feel good."