Despicable Me (2010–2022)

In 2010, Brand became a fixture of global family entertainment by voicing elderly gadget inventor Dr. Nefario in Illumination's Despicable Me, returning for the 2013 sequel and 2022's Minions: The Rise of Gru. His involvement in one of cinema's biggest children's franchises kept him embedded in mainstream pop culture for more than a decade before his past caught up with him.