Shannen Doherty, Holly Marie Combs and Alyssa Milano: The Halliwell Sisters (Charmed, 1998–2006)

This iconic trio completely redefined modern supernatural television, turning the Halliwell sisters into a comforting pop-culture institution for a generation of fans. Alongside Holly Marie Combs as the time-freezing middle sister Piper and Alyssa Milano as the premonition-wielding youngest sister Phoebe, it was the late Shannen Doherty’s commanding, fiercely protective performance as telekinetic Prue Halliwell that anchored the legendary "Power of Three".

Doherty’s spellbinding arc saw Prue transform from a conservative eldest sibling into an all-powerful, prideful, leather-clad, demon-slaying bad-ass witch.

Her presence defined the early, Gothic-gritty era of the show back when it leaned into a darker, Buffy-esque vibe.

However, Prue's shocking on-screen death at the end of season three severed the original trinity and altered the show's dynamic forever, sending Charmed in a much more fantastical direction.

Though Rose McGowan’s telekinetic-orbing Paige Matthews did a fantastic job stepping into the coven to reconstitute their magic, the raw, original sisterly bond was never quite the same.