George Clooney as Doug Ross in ER (1996-1999)
According to George Clooney you don't mess with the original.
He said: "When you look at the show, over so many years, it would be hard to say you could do it at the level that we did it. It's hard to catch lightning in a bottle again."
Next, Gene Wilder in Willy Wonka and the Chocolate Factory (1971) ...